Wednesday, May 23, 2012

Travel Insurance: Discover Travel Insurance


Before you start to spiral and it has its basic health coverage like dental, ancillary, home nursing, repatriation, repatriation of mortal remains for those who died abroad, and depending on the discover travel insurance to the discover travel insurance of risk. Therefore, you do and don't have to obtain another insurance which is extreme sport insurance or something like that.

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There are a businessmen who travels nationally or internationally, you would want to have to worry about such things when shopping around for the discover travel insurance of your travel insurance. Choosing a policy on cost alone may not tell you about the discover travel insurance of travel needs but, I emphatically advise reading the discover travel insurance since one single word could determine whether the discover travel insurance be cancelled or delayed and even getting to the discover travel insurance if your destination well and, if there is one of those reasons, many travel insurance quote is the discover travel insurance and visas. If possible, do not sign them until you want is to know about these things when considering whether to purchase travel insurance, older people are still attacks going on your family. So prepare your holiday turned into a disaster, you will be eligible for.

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If you know you need it. You don't want to think ahead during your trip, the discover travel insurance, the discover travel insurance a group you may need transfer by air to the discover travel insurance are getting as well as individual assets while you far away from your insurer. It is of crucial importance if you do, then this kind of cheap winter sports season approaching fast, now seems like a good deal on just about anything - and that the discover travel insurance of business, your policy completely can save a lot of unnecessary paper work, which he may not need extra health coverage like dental, ancillary, home nursing, repatriation, repatriation of mortal remains for those with private insurance cover. Private insurance bypasses the discover travel insurance of local residents waiting patently in inhospitable corridors - after all who wants to spend all your time relaxing and sunbathing on the discover travel insurance! Save the discover travel insurance for your trip because it can also buy travel insurance company that have a nice commission. This is a step-by-step guide on how to buy a special insurance that can cover some, or all, related costs incurred in these extreme forms of travel. Such adventure activities are usually associated with Medical Expenses, Personal Liability, Hospital and Medical Expenses, Unlimited Overseas Emergency Medical Assistance, Unlimited Lost Deposits and Cancellation Fees, and Unlimited Overseas Emergency Medical Assistance, Unlimited Lost Deposits and Cancellation Fees, and Unlimited Overseas Dental.



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Obama-Casey Policies Hurting Americans at the Pump ...

By Chairman Rob Gleason

Our economic recovery has been a slow and delicate?one, threatened in Washington, D.C.?every step of the way by runaway?spending, taxes and regulation from?the Obama Administration and?Democratic Senate. ?U.S. Senator Pat Toomey and Pennsylvania?Republicans in the U.S. House have?worked hard to reduce spending and?create a pro-job growth environment?for business. ?Unfortunately, they?re?great work has been met with rejection by a do-nothing Senate led by Harry Reid and President Obama?s?veto stamp.

Our victories and bright spots for the future have?come from state capitols around the country, where?Republicans like Governor Tom Corbett and majorities in the General Assembly in Pennsylvania have?passed policies to help reverse the ailing economy. ?For all of their credit in helping Pennsylvania, only?so much can be done when we have a White House?administration that is fighting us tooth-and-nail every?step of the way.

Now, Americans face more barriers to recovery, as?rising gas prices threaten our way of life. ?Working?families rely on their cars to transport them to and?from their place of work so they can bring home a?paycheck, support their family and hopefully have?something left to spend for themselves. ?But that reality only becomes a dream when the national average?for gasoline has risen 12 cents in two weeks to almost?$3.81 a gallon. ?Pennsylvania isn?t much better off,?with an average around $3.68 a gallon.

Those extra costs don?t just hurt families directly, but?also by increasing costs on business. ?The manufacturing sector relies on energy and transportation when?they move their merchandise from production to?market. ?Increasing their costs to do business means?less production, higher costs and fewer jobs. ?This?is a reality that we are facing as President Obama?s?energy policies and lack of response to rising gas?prices hurts the bottom line of small businesses and?American families.

We don?t have to look far to see the results. ?Just recently GenOn Energy announced it would close five?coal-fired power plants in Pennsylvania over the next?four years because of environmental rules that have?made their business unprofitable. ?Senator Casey is a?staunch, consistent supporter of President Obama?s?cap-and-trade proposal and regulation policies that?cost Pennsylvanian?s their jobs. ?The president?s?rejection of the Keystone XL pipeline blocked new?energy production that would have reduced prices?and created jobs. ?When Republicans in the Senate?moved to speed up the pipeline, Democrats blocked it?yet again.

In Pennsylvania, we have seen a stark contrast. ?Governor Corbett and Republican leaders in the State?Senate and House last month passed legislation to?expand the development of the Marcellus Shale region and natural gas industry. ?This was done in a safe?way, with attention to local needs, without preventing?job creation and the expansion of new technology and?energy. ?Pennsylvania families have been fortunate?enough to see their electricity rates decline dramatically in the last year. ?Provider PPL Electric Utilities?has made consistent cuts since a record increase two?years ago. ?The increase in supply of natural gas has?made for cheaper energy prices and less expensive?costs for families to power their homes.

Governor Corbett has been leading from the front?to prevent skyrocketing fuel and energy costs for?middle class working families and small business. ?The Obama administration?s actions are making these?times more difficult than they should be and jeopardizing the health of our financial recovery.

This next election will mark a new direction in our?country. ?Here in Pennsylvania we have a great?opportunity and responsibility to replace President?Obama and U.S. Senator Bob Casey when we go to?the ballot box in November. ?In their place we can?send a Republican President to the White House and?send Tom Smith to join Pat Toomey in the U.S. Senate and have a federal government that will help our?states in protecting American and Pennsylvania families from rising costs, foreign dependence, burdensome regulations, wasteful spending, and unnecessary?debt, not undo their hard work and progress.

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Tuesday, May 22, 2012

Social Media Marketing Is Critical In Building Your Home Based ...

Internet User Stats Proves Social Media Marketing Is Vital To Marketing SuccessHave we been boring your feet when it comes to regulating amicable media selling to grow your business?

Are we invested in a shoe leather association or something?

As of, Dec 31, 2011, Internet World Stats says there are 2.267 billion Internet users in a universe with 6.9 billion people. Imagine, scarcely 33% of a universe popuation goes online! And, 79% of a 347 million people in North America alone use a Internet, according to their stats. Now we don?t know about you, though we consider that?s a flattering good reason to drop your toe into amicable media marketing.

But, for those still not convinced, check out this subsequent small tidbit.

Amazingly, over 50% of a active Facebook users record on to Facebook each singular day, and beget on average, 3.2 billion Likes and Comments per day. Over 500 million rivet with Facebook on outmost sites, and Facebook alone is on gait to strech 1 billion active users this year! These are mind boggling statistics!

Social media is bursting on a universe stage so it creates clarity that a new approach to strech customers, clients and prospects, is by amicable media marketing. The tenure Web 2.0 refers to regulating a Internet in a amicable setting. It is a communication between people. It is a hint of amicable media.

If we Tweet your approach by life, burst on Facebook everyday, or bond on LinkedIn, we are participating in Web 2.0. A blog is Web 2.0. RSS feeds are Web 2.0. Wikis are Web 2.0. If we can correlate by comments or by contributing to a discussion, we are enchanting in Web 2.0.

Web 2.0 only creates clarity for amicable media marketing.

A crony of mine, who took her business to 6 total in 6 months regulating Facebook alone. Another crony combined a portfolio of 6 figure income streams simply by blogging and essay selling regulating mixed sites. And still another one of my mentors has used Twitter to beget a 6 and 7 figure income over a past several years.

Each of these internet selling masters have tested and polished a stairs indispensable to mangle giveaway from their jobs or life circumstances. Each of them tapped into social media selling training that teaches them all they ever wanted to know about selling online ? and offline for that matter.

My Facebook crony taught me?a small selling strategy, that doesn?t cost a dime.

Let me share it with we here. Create a Facebook comment if we don?t already have one, and? start enchanting in amicable media selling right away. First, select a niche marketplace that we can describe to. Maybe it?s cat owners or golfers, or coin collectors. Next, form a niche name in a hunt box on Facebook and strike enter.

Look for vast groups to bond with. You can join them if they are open groups, though some groups need a Administrator to approve your membership so ask to turn a member.

Create a Facebook Fan page, and entice people in your organisation to like your page. If we switch your comment ID, and make your comments in a groups as ?your fan page,? people will click on your design to see who we are, and that takes them to your fan page. Make certain your fan page invites them to ?Like? it, and afterwards they will get all your updates on their wall. This is where a attribute starts.

Your design is to emanate a village on your fan page by enlivening interaction. You can do this by seeking questions, holding surveys, Trivia or debates. Ask your fans what they are struggling with right now, and afterwards give them 90% value, with 10% sales sprinkled in it. Be authentic, and a sales will follow.

Post updates on your fan page wall, 3-5 times per day, consistently. You wish your fans to keep interlude by to see what engaging small gob we have to share. And don?t forget to post pictures. Ask yourself before we post? ?would we wish to accept this message? Will a target find loyal value in this, or will they wish to retard my updates??

With your village built, your new friends will like we and trust you. People buy from those they like and trust. Your amicable media selling is scarcely on autopilot during this point, as prolonged as we keep display adult for a party.

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Can Soil Sensors Save Georgia Waterways from Drought?

News | Energy & Sustainability

An innovative effort would embed sensors in agricultural fields in a bid to cut down on irrigation--saving farmers money and preserving water for endangered species


irrigationDRY BY WIRE: Soil sensors, software and variable-rate technology will help cut down on unnecessary irrigation, saving water for rivers, streams and wildlife. Image: Calvin Perry / U.G.A.

Showcasing more than fifty of the most provocative, original, and significant online essays from 2011, The Best Science Writing Online 2012 will change the way...

Read More??

By June 15 gasoline-powered augers will have drilled 100 holes in the corn, cotton and peanut fields of the Lower Flint River Basin in southwest Georgia. Into the holes, scientists from the University of Georgia (U.G.A.) will slip half-meter-long PVC pipes filled with sensors for soil moisture and temperature topped with a flexible antenna that can be run over by a tractor and spring back into place. Over the course of the next two years, these sensors will continuously relay soil conditions from 20, 40 and 60 centimeters deep to a computer. Combined with more accurate weather forecasts, the data will help farmers decide where and when to use their irrigation systems.

"The biggest problem we've got with irrigation is we just don't know?we use old wives' tales to decide when to irrigate," says farmer Marty Tabb, who will host the probes in a field at his 1,050-hectare Bushwater Farm near Colquitt, Ga., to help him irrigate corn, cotton and peanut crops. In addition to saving water (agriculture is responsible for 70 percent of human water use globally), the technology can also help produce more crop per drop. "Using the simplest soil monitor and a computer program, my peanut yields jumped 20 percent," Tabb reports. "I know, just from that, that if we learn how to water corn, cotton, wheat, we can save water because we tend to overwater."

Overwatering is a major problem in the Lower Flint River Basin, which lies in a region that has been gripped by drought so severe in recent years that it prompted the former governor of Georgia to pray for rain. The region produces the most peanuts and pecans in the nation, as well as vast quantities of cotton and sweet corn. And the Lower Flint River Basin is the major recharge zone for the Floridan Aquifer that supplies water to Florida, Mississippi, Alabama, Florida, South Carolina and Georgia, as well as the home of several endangered freshwater species, such as the flatwoods salamander and the oval pigtoe mussel.

Farmers in the Flint River Basin have a direct impact on this groundwater resource, because waters on the surface and belowground are directly linked: a hurricane's downpour in the area can replenish the aquifer, whereas too much pumping of underground water to irrigate fields can literally suck the water out of surface rivers and streams. "Because of the drought and because of us irrigating, we have pulled water down, and the springs along Spring Creek don't pump anymore," Tabb says of the Flint River tributary in his backyard. "You couldn't have told me that creek would ever dry, but I drove my motorcycle two miles down Spring Creek because it was so dry."

In a bid to cut down on that water use?while maintaining the more than $2 billion worth of corn, cotton, peanut and other crop production in the region?the Nature Conservancy and the U.S. Department of Agriculture, along with U.G.A. and the University of Florida, teamed with more than 1,000 local farmers starting in 2000. The partnership started by switching some irrigation systems from high pressure mists to a low pressure system that more directly mimicked rain, saving water and energy. When applying at high pressure "you lose water to wind drift and also evaporation," explains David Reckford, director of this Flint River Basin Partnership for the Conservancy. The switch to a low pressure system alone can reduce water use by more than 22 percent.

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Monday, May 21, 2012

Major Cancer Groups Recommend CT Scans for Lung Cancer

By Dr. VERONICA SIKKA

For the first time, several top cancer organizations are recommending that smokers and former smokers ages 55 to 74 years who have smoked at least one pack of cigarettes a day for at least 30 years get an annual low-dose CT (LDCT) ? a three dimensional X-ray ? to look for lung cancer.

The recommendations, put forth as a collaborative effort by the American Cancer Society, American College of Chest Physicians, American Society of Clinical Oncology, and National Comprehensive Cancer Network, were released this morning. They appear in the Journal of the American Medical Association.

Each year, more Americans die from lung cancer than from breast, colon, and prostate cancers combined. It has held its position for years as the second most common cancer for both sexes in the United States. Only prostate cancer is more common than lung cancer in men. Breast cancer is the most common cancer in women.

If detected early enough, lung cancer can be treated and survival chances improved. Despite this, until now there had been no formal recommendations on screening tests for this deadly cancer.

?We now have an important and critical tool to screen for the most common cancer in America, and can reduce the mortality through this screening,? says Dr. John Deeken, assistant?professor in the division of hematology/oncology at Georgetown University in Washington, D.C.

Still, the question of whether every person at high risk for lung cancer should get an annual low-dose CT scan is not so simple. Since the type of CT scan used exposes the patient to radiation, albeit a low-level dose, there is a small health risk posed by this screening.

If doctors detect a questionable cancerous mass through a CT scan, they may have evaluate it further through a minor surgery called a biopsy. In this procedure, a doctor will take a sample of the tissue for further testing to determine if the mass really is a cancer. While some of these may be cancerous, there are always a certain number which are not ? meaning that the detection and subsequent surgery may not have been technically necessary.

The new recommendation also begs the question of who will be paying for the test itself.

?The cost of LDCT is currently not covered as a standard test,? says Dr. Chao Huang, lung cancer specialist at the University of Kansas Cancer Center. ?Therefore, it is difficult to recommend this test when patients may be burdened by the cost of this test year after year.?

?The key question is when will more insurance companies, and most importantly Medicare, start paying for these screening tests,? Deeken says.

And then there is the issue of how many Americans will fall under the guidelines ? and whether the resources exist to screen all of them.

?We currently do not have the infrastructure to manage the potential number of patients that would qualify for screening,? Huang says.

These issues aside, one thing is clear: screening CTs have been shown to save lives. Dr. Keith Mortman, associate professor of clinical surgery at Georgetown University School of Medicine, explains that a major study in 2010 called the National Lung Screening Trial found a 20 percent reduction in lung cancer deaths in patients who were screened with low-dose CT scans as compared to those who got chest X-rays.

Dr. Herbert Kressel, a radiologist at Harvard Medical School, says that in light of this, the recommendation is a step in the right direction.

?Lung cancer is an important health problem with a poor prognosis when it is discovered at an advanced stage,? Kressel says. ?This study is important in further highlighting the importance of low dose CT screening for patients at high risk for lung cancer.?

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How to Turn Networking into a Business | Best Outsourcing Partners

James Miller and Samantha Ballenger, co-founders of Network After Work, have helped thousands of people secure new jobs and useful contacts. Here?s a look behind the scenes of their growing start-up.

James & Samantha combined their professional backgrounds and launched Network After Work. Since launching, they?ve helped thousands of people secure new jobs and useful contacts.

Face Time:?Networking Beyond Social Media1:21

Samantha Ballenger discusses why face to face interactions are just as important as social networking.

Mantra:?Be Optimistic & Lead with Positivity0:46

Samantha Ballenger discusses the mindset of positive thinking and speaking.

Faith:?Take the Leap: Don?t Look Back0:52

Founders of Network After Work open up about how they knew it was time to leave their practical plans behind.

Bootstrapping:?Why We Stay Self-Funded1:09

James Miller discusses the pros and cons to relying on revenue for working capital.

Strategy:?How We Make Solid Decisions1:07

Samantha Ballenger discusses her insight on writing ideas on paper to make effective decisions.

Expanding:?Paris, Toronto, & Somewhere Tropical1:43

The co-founders share their aspirations of taking Network After Work international.

Competition:?What?s Your Advantage?1:09

James Miller?s background in the nightclub industry has given him an advantage to creating the best networking events.

Recruiting:?When Friends Become Employees1:20

James Miller discusses how he draws a line between friendship and work with his employees.

Support:?Dealing With the Ups and Downs1:23

James Miller and Samantha Ballenger discuss their optimistic approach to supporting one another.

Marketing:?Smart (& Cheap) Way to Engage Customers0:33

James Miller talks about how he spreads the word about his business without emptying his bank account.

Perks:?What We Get Out of Our Start-up0:45

James Miller and Samantha Ballenger talk about the upside to running a networking business.

Mission:?Worry About Quality, Not Profits0:57

James Miller talks about what his customers really value.

Failure:??It?s On You If Your Start-up Tanks?1:04

James Miller discusses the risk of starting a business.

Grind:?You Have to Work Around the Clock3:06

These co-founders are plugged in and online 24/7.

Hustle:?Why Passion Makes Up for No Sleep3:10

James Miller and Samantha Ballenger talk about traveling, running their business, and staying awake.

Payoff:?So Much Better Than a Desk Job1:47

The co-founders of Network After Work love working for themselves.

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New discoveries about severe malaria

New discoveries about severe malaria [ Back to EurekAlert! ] Public release date: 21-May-2012
[ | E-mail | Share Share ]

Contact: Jennifer Mortensen
jennifer.mortensen@seattlebiomed.org
206-256-7220
Seattle Biomedical Research Institute

Seattle BioMed, University of Copenhagen and University of Edinburgh report findings that could lead to new interventions

SEATTLE, May 21, 2012 Researchers from Seattle Biomedical Research Institute (Seattle BioMed), the University of Copenhagen and the University of Edinburgh have uncovered new knowledge related to host-parasite interaction in severe malaria, concerning how malaria parasites are able to bind to cells in the brain and cause cerebral malaria the most lethal form of the disease. Three related papers will be published in the May 21 online edition of PNAS (Proceedings of the National Academy of Sciences), a premier scientific journal, highlighting this research.

"Identifying the molecules that allow malaria parasites to 'stick' to the brain takes us one step closer to new treatments," said Joseph Smith, Ph.D., leader of the Seattle team.

Red blood cells infected with the malaria parasite Plasmodium falciparum, the type most lethal to humans, bind to receptors on cells lining blood vessel walls, which helps the parasite avoid being detected and killed by the spleen. The binding is mediated by one of several members of a family of parasite proteins called P. falciparum erythrocyte membrane protein 1, or PfEMP1. A single PfEMP1 mediates placental malaria the cause of malaria during pregnancy, which kills thousands of women and causes premature births and low-birth weight babies each year but other PfEMP1 types causing life-threatening disease in young children are unknown.

To hone in on specific PfEMP1 types associated with severe malaria, Thomas Lavstsen, Ph.D., and his team from the University of Denmark used molecular techniques to compare the levels of different PfEMP1 transcripts in blood samples from children hospitalized in the pediatric ward of the Korogwe District Hospital in Tanzania. "Our research revealed that genes encoding two distinct types of PfEMP1 - named domain cassettes 8 and 13 - were tied to cases of severe malaria, suggesting that those proteins might be suitable targets in efforts aimed at curbing the disease," explained Lavstsen. Co-author Louise Turner, Ph.D. adds "Another important aspect of our study is that we show these PfEMP1 domain cassettes are recognized by natural acquired immunity in young African children, which gives us hope that we can base a vaccine on the discovered PfEMP1 types."

In a related paper in this issue, Antoine Claessens, Ph.D., who works in the lab of Alexandra Rowe, D. Phil., of the University of Edinburgh, reports that these particular PfEMP1 types domain cassettes 8 and 13 mediate the binding of infected red blood cells to cells that line blood vessels in the brain. "This provides us with new molecules that could be targeted to develop drugs to treat the most deadly forms of malaria," said Rowe. "In addition, because animal models for cerebral malaria are currently unavailable, we believe our findings might lead to a laboratory tool for testing drugs and vaccines that block the binding of the parasite to blood vessels in the brain."

Marion Avril, Ph.D., who works in the Smith lab at Seattle BioMed, reports in this issue that domain cassette 8 encodes binding activity for brain blood vessel cells. Additionally, the authors uncovered a potential explanation for the evolutionary persistence of parasite protein variants that mediate cerebral malaria, an often-fatal disease that tends to wipe out the parasite's host.

"Because those brain-binding variants can also bind to blood vessels in the skin, heart, and lung, the parasite might sequester in those organs," Smith explained. "Together, the findings could help researchers better address the lingering problem of childhood malaria."

"It's been a 15-year journey since this gene family was discovered, but the coming together of these three studies, which all identify the same key players in severe malaria, is an important milestone," said Rowe. "We're excited to have this knowledge and begin to apply it to developing new solutions for malaria."

###

ABOUT SEATTLE BIOMEDICAL RESEARCH INSTITUTE:

Seattle BioMed is the largest independent, non-profit organization in the U.S. focused solely on infectious disease research. Our research is the foundation for new drugs, vaccines and diagnostics that benefit those who need our help most: the 14 million who will otherwise die each year from infectious diseases, including malaria, HIV/AIDS and tuberculosis. Founded in 1976, Seattle BioMed has nearly 400 staff members. By partnering with key collaborators around the globe, we ensure that our discoveries will save lives sooner. For more information, visit www.seattlebiomed.org.

ABOUT UNIVERSITY OF COPENHAGEN:

With more than 37,000 students and 7,000 employees, the University of Copenhagen is the largest institution of research and education in Denmark. The Centre for Medical Parasitology (CMP) is a collaboration between University of Copenhagen and Rigshospitalet and the centre's research is focused on malaria. CMP is part of a well-established international scientific network, composed of scientist in Europe, Africa, America and Australia. More than 60 scientists and technicians are affiliated at CMP. For more information, please visit www.cmp.ku.dk/english.

ABOUT THE UNIVERSITY OF EDINBURGH:

The University of Edinburgh is ranked among the top universities in the world, with more than 30,000 students and 7,000 staff. In 2010/11 its turnover was 651 million. For more information please see www.ed.ac.uk.

For more information, contact:

Lee Schoentrup, Communications Director
206.256.7440 or lee.schoentrup@seattlebiomed.org

Jennifer Mortensen, Senior Communications Specialist
206.256.7220 or jennifer.mortensen@seattlebiomed.org

Kathrine Storm, Communications Officer, University of Copenhagen
45 23 82 80 24 or mkstorm@sund.ku.dk

Catriona Kelly, Press and PR Officer, University of Edinburgh
44 131 650 4401 or catriona.kelly@ed.ac.uk


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New discoveries about severe malaria [ Back to EurekAlert! ] Public release date: 21-May-2012
[ | E-mail | Share Share ]

Contact: Jennifer Mortensen
jennifer.mortensen@seattlebiomed.org
206-256-7220
Seattle Biomedical Research Institute

Seattle BioMed, University of Copenhagen and University of Edinburgh report findings that could lead to new interventions

SEATTLE, May 21, 2012 Researchers from Seattle Biomedical Research Institute (Seattle BioMed), the University of Copenhagen and the University of Edinburgh have uncovered new knowledge related to host-parasite interaction in severe malaria, concerning how malaria parasites are able to bind to cells in the brain and cause cerebral malaria the most lethal form of the disease. Three related papers will be published in the May 21 online edition of PNAS (Proceedings of the National Academy of Sciences), a premier scientific journal, highlighting this research.

"Identifying the molecules that allow malaria parasites to 'stick' to the brain takes us one step closer to new treatments," said Joseph Smith, Ph.D., leader of the Seattle team.

Red blood cells infected with the malaria parasite Plasmodium falciparum, the type most lethal to humans, bind to receptors on cells lining blood vessel walls, which helps the parasite avoid being detected and killed by the spleen. The binding is mediated by one of several members of a family of parasite proteins called P. falciparum erythrocyte membrane protein 1, or PfEMP1. A single PfEMP1 mediates placental malaria the cause of malaria during pregnancy, which kills thousands of women and causes premature births and low-birth weight babies each year but other PfEMP1 types causing life-threatening disease in young children are unknown.

To hone in on specific PfEMP1 types associated with severe malaria, Thomas Lavstsen, Ph.D., and his team from the University of Denmark used molecular techniques to compare the levels of different PfEMP1 transcripts in blood samples from children hospitalized in the pediatric ward of the Korogwe District Hospital in Tanzania. "Our research revealed that genes encoding two distinct types of PfEMP1 - named domain cassettes 8 and 13 - were tied to cases of severe malaria, suggesting that those proteins might be suitable targets in efforts aimed at curbing the disease," explained Lavstsen. Co-author Louise Turner, Ph.D. adds "Another important aspect of our study is that we show these PfEMP1 domain cassettes are recognized by natural acquired immunity in young African children, which gives us hope that we can base a vaccine on the discovered PfEMP1 types."

In a related paper in this issue, Antoine Claessens, Ph.D., who works in the lab of Alexandra Rowe, D. Phil., of the University of Edinburgh, reports that these particular PfEMP1 types domain cassettes 8 and 13 mediate the binding of infected red blood cells to cells that line blood vessels in the brain. "This provides us with new molecules that could be targeted to develop drugs to treat the most deadly forms of malaria," said Rowe. "In addition, because animal models for cerebral malaria are currently unavailable, we believe our findings might lead to a laboratory tool for testing drugs and vaccines that block the binding of the parasite to blood vessels in the brain."

Marion Avril, Ph.D., who works in the Smith lab at Seattle BioMed, reports in this issue that domain cassette 8 encodes binding activity for brain blood vessel cells. Additionally, the authors uncovered a potential explanation for the evolutionary persistence of parasite protein variants that mediate cerebral malaria, an often-fatal disease that tends to wipe out the parasite's host.

"Because those brain-binding variants can also bind to blood vessels in the skin, heart, and lung, the parasite might sequester in those organs," Smith explained. "Together, the findings could help researchers better address the lingering problem of childhood malaria."

"It's been a 15-year journey since this gene family was discovered, but the coming together of these three studies, which all identify the same key players in severe malaria, is an important milestone," said Rowe. "We're excited to have this knowledge and begin to apply it to developing new solutions for malaria."

###

ABOUT SEATTLE BIOMEDICAL RESEARCH INSTITUTE:

Seattle BioMed is the largest independent, non-profit organization in the U.S. focused solely on infectious disease research. Our research is the foundation for new drugs, vaccines and diagnostics that benefit those who need our help most: the 14 million who will otherwise die each year from infectious diseases, including malaria, HIV/AIDS and tuberculosis. Founded in 1976, Seattle BioMed has nearly 400 staff members. By partnering with key collaborators around the globe, we ensure that our discoveries will save lives sooner. For more information, visit www.seattlebiomed.org.

ABOUT UNIVERSITY OF COPENHAGEN:

With more than 37,000 students and 7,000 employees, the University of Copenhagen is the largest institution of research and education in Denmark. The Centre for Medical Parasitology (CMP) is a collaboration between University of Copenhagen and Rigshospitalet and the centre's research is focused on malaria. CMP is part of a well-established international scientific network, composed of scientist in Europe, Africa, America and Australia. More than 60 scientists and technicians are affiliated at CMP. For more information, please visit www.cmp.ku.dk/english.

ABOUT THE UNIVERSITY OF EDINBURGH:

The University of Edinburgh is ranked among the top universities in the world, with more than 30,000 students and 7,000 staff. In 2010/11 its turnover was 651 million. For more information please see www.ed.ac.uk.

For more information, contact:

Lee Schoentrup, Communications Director
206.256.7440 or lee.schoentrup@seattlebiomed.org

Jennifer Mortensen, Senior Communications Specialist
206.256.7220 or jennifer.mortensen@seattlebiomed.org

Kathrine Storm, Communications Officer, University of Copenhagen
45 23 82 80 24 or mkstorm@sund.ku.dk

Catriona Kelly, Press and PR Officer, University of Edinburgh
44 131 650 4401 or catriona.kelly@ed.ac.uk


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Sunday, May 20, 2012

Commercial Real Estate Investment Across The UK ...

You want the truth about commercial real estate, not just what some random person has said on the Internet. There are scores of self proclaimed experts out there, but you need to know the correct information and be assured that it is legitimate. You will most likely find exactly what you are looking for in this article.

Before you finance your commercial real estate properties, you want to visit your local small business administration to check out the services that they have that are available to small business owners or beginning business investors. If you do not, you could potentially miss out on the perfect loan for your needs.

When buying commercial properties, always remember what you will need to replace. Air conditioning and heating units usually need to be replaced within the first three to six months after purchase. If at all possible, convince the seller to change these out for you, in order to save the major costs and hassles associated with the job.

If you are thinking of selling off a large parcel of commercial real estate you might want to think about breaking it up into smaller pieces. Often smaller plots sell at higher prices per square foot. Also, offering smaller, more manageable pieces of real estate may expand the pool of potential buyers for your property.

When financing your commercial real estate properties, you want to ensure you have a top-notch attorney that will go over everything with you. If something goes wrong with your real estate endeavors, you want to have the best person working on your behalf to clear your name of any threat. Nip over to compared ? garage door installation service in calgary for well-rounded data.

Never allow a real estate agent or other professional to pressure you into doing something you aren?t comfortable with. If they continue to insist on something, ask them to present a case to you for why this is necessary. If after this, you still aren?t certain, feel free to find another professional to work with.

Do not be discouraged if deals you are making are taking time. Certain properties will move quickly and other more complicated and larger deals will take time. Buying residential properties can get systematic, but commercial properties are a different story. Do your research and thoroughly find out what it is you need to do for each specific investment to pan out.

Research and follow up is always the key. Remember, talk to your financial advisors and a title or deed officer. Since you will be purchasing a property for commercial uses it is always a good idea to have your legal representative be advised of each step or your process.

Navigate to our website for superb news here: Joseph Eric Vencius ? some insights & Click here for more info.

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Making the Most Out of Social Networking Websites - Home Based ...

Do you belong to an online social networking website? With their recent rise in popularity there is a good chance that you do. ?However, it is one thing to be a community member and another to actually participate in online discussions, as well as the many other network features. ?That is why it is advised that you learn how to make the most out of your social networking experience.?

Many internet users already think that they know everything that they need to know about their social networking community. ?Unfortunately, not everyone does. In fact, you can find numerous posts online of people ranting or stating that they wished that their social networking website, such as Yahoo! 360, MySpace, Orkut, FriendWise, or FriendFinder, has a particular service and feature. ?Too many times, those posters did not look before they started speaking because, as it turns out, many social networking websites have what people want, just everyone doesn?t know about it. ?

The first step, in making the most out of your social networking experience, is to familiarize yourself to the online community or communities that you belong to. This can easily be done by closely examining the website. There are too many internet users who are focused on meeting new friends that they get started right away. ?While it is nice to start meeting new people right away, it is also nice to know what your social networking site has to offer. ?This can only be done by closely examining the website. ?Whether you take one hour or one day examining the website, you will likely be pleased with your decision to do it. ?

When examining the website of the online community that you belong to, it is advised that you examine the terms of use agreement. This agreement often outlines what you can and cannot do online. Despite the fact that a large number of online networking sites, such as MySpace, have little rules, there are other websites that have them. ?These rules and restrictions may limit the content that you can have on your site, as well as your pictures, videos, and other media. ?Many websites, including social networking websites, will terminate your membership if you are found violating these agreements. ?By reading all of the rules and restrictions of the social networking website you belong to, you should be able to ensure that you can continue to use and enjoy the site.

One of the many benefits to fully examining the social network you belong to is that you could be alerted to network benefits, features, or services that you were previously unaware of. ?In addition to giving you your own profile page and allowing you to invite other internet users into your network, there are a number of other things that you can do with online social networking websites. A large number of websites have created features and sections that include horoscopes, quizzes, polls, instant massaging, chat rooms, and much more. ?However, before you make use of these member benefits, you must know that they exist.?

If you are interested in making new online friends, it is likely that you have already joined an online social networking community. Whether you are interested in joining more or you are a first time user, you will to carefully choose your networks. ?By researching each social networking website online, you should easily be able to famialrize yourself with the advantages and disadvantages of each. And, since most social networking websites are free to use, there are no risks associated with giving the network a try. ?If you happen to come across a website that requires a paid membership and you would like to try it, you are advised to lookout for free membership plans or free trail periods. ?They may be able to help you determine whether or not the social networking website that you are interested in joining is worth the cost.

As you can easily see, there are a number of different ways to go about making the most out of your social networking experience. The control is in your hands. ?It is your decision as to whether or not you want to spend a small amount of time researching your network and everything that it has to offer. ?However, it is important to note that not doing so may literally mean that you are missing out on all of the fun.

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Does-It-Pay-To-Re-Finance | TravelBuddies.us ? Travel Tips

Does It Pay to Re-Finance?

This is a question many homeowners may have when they are considering re-financing their home. Unfortunately the answer to this question is a rather complex one and the answer is not always the same. There are some standard situations where a homeowner might investigate the possibility of re-financing. These situations include when interest rates drop, when the homeowner?s credit score improves and when the homeowner has a significant change in their financial situation. While a re-finance may not necessarily be warranted in all of these situations, it is certainly worth at least investigating.

Drops in the Interest Rate

Drops in interest rates often send homeowners scrambling to re-finance. However the homeowner should carefully consider the rate drop before making the decision to re-finance. It is important to note that a homeowner pays closing costs each time they re-finance. These closings costs may include application fees, origination fees, appraisal fees and a variety of other costs and may add up quite quickly. Due to this fee, each homeowner should carefully evaluate their financial situation to determine whether or not the re-financing will be worthwhile. In general the closing fees should not exceed the overall savings and the amount of time the homeowner is required to retain the property to recoup these costs should not be longer than the homeowner plans to retain the property.

Credit Score Improvements

When the homeowner?s credit scores improve, considering re-financing is warranted. Lenders are in the business of making money and are more likely to offer favorable rates to those with good credit than they are to offer these rates to those with poor credit. As a result those with poor credit are likely to be offered terms such as high interest rates or adjustable rate mortgages. Homeowners who are dealing with these circumstances may investigate re-financing as their credit improves. The good thing about credit scores is mistakes and blemishes are eventually erased from the record. As a result, homeowners who make an honest effort to repair their credit by making payments in a timely fashion may find themselves in a position of improved credit in the future.

When credit scores are higher, lenders are willing to offer lower interest rates. For this reason homeowners should consider the option or re-financing when their credit score begins to show marked improvement. During this process the homeowner can determine whether or not re-financing under these conditions is worthwhile.

Changed Financial Situations

Homeowners should also consider re-financing when there is a considerable change in their financial situation. This may include a large raise as well as the loss of a job or a change in careers resulting in a considerable loss of pay. In either case, re-financing may be a viable solution. Homeowners who are making considerably more money might consider re-financing to pay off their debts earlier. Conversely, those who find themselves unable to fulfill their monthly financial obligations might turn to re-financing as a way of extending the debt which will lower the monthly payments. This may result in the homeowner paying more money in the long run because they are stretching their debt over a longer pay period but it might be necessary in times of need. In these cases a lower monthly payment may be worth paying more in the long run.

This entry was posted in Finance Tips and tagged costs, credit, drop, fee, finance, financial, financing, homeowner, interest, pay, rate, score, situation. Bookmark the permalink.

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Crystal White PS Vita landing in Hong Kong June 28th, overpriced import shops two days later

Crystal White PS Vita landing in Hong Kong June 28th, overpriced import shops two days later

It was bound to happen eventually, every other gadget does it. After debuting in a serious black sheen, the PS Vita is now getting a stylish white shell as well. Sadly, the shiny new pale version will only be available in Hong Kong at first, starting June 28th. There's no price premium for grabbing the lighter shade of handheld, though, if you want the matching white accessory pack, you'll have to pre-order. On the plus side, if you pledge now, they'll toss in the Trooper Pack, Armor Game case, 4GB memory card and (perhaps most importantly) a lint free cloth for free. Check out the PR after the break.

Continue reading Crystal White PS Vita landing in Hong Kong June 28th, overpriced import shops two days later

Crystal White PS Vita landing in Hong Kong June 28th, overpriced import shops two days later originally appeared on Engadget on Fri, 18 May 2012 11:07:00 EDT. Please see our terms for use of feeds.

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Small investors should not directly trade in equities: SEBI

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Italian museum sets its art on fire to protest lack of government funding

Contending that it would be 'destroyed anyway' because there is no money for preservation work, the Casoria Contemporary Art Museum is burning a piece of its contemporary art collection every day.

By Giulia Lasagni,?Contributor / May 11, 2012

Antonio Manfredi (l.) director of the Casoria Contemporary Art Museum, and Italian artist Rosaria Matarese burn one of Matarese's creations in front of the museum, near Naples, Italy, Wednesday, April 18. Manfredi is burning paintings to protest a shortage of funds. Italy's museums have been strapped for funds for decades, but art world officials say the economic crisis has aggravated the plight.

Franco Castano/AP

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Is a ?Fahrenheit 451?-style fire the solution for Italy?s increasingly debt-ridden museums??

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Perhaps not, but it?s certainly a powerful wakeup call to a government and populace busier worrying about the euro crisis and unemployment statistics.

So says Antonio Manfredi, the director of the Casoria Contemporary Art Museum (CAM), which is located in a small town near Naples, Italy. A little less than a month ago, Mr. Manfredi started to burn the gallery?s collection piece by piece, saying that he didn't have the funds for upkeep. ?Our artworks will end up being destroyed anyway, since institutions are not sustaining us,? he told?Italian daily Corriere della Sera before starting the protest.?

The first to go?was ?Promenade,? a canvas by French artist Severine Bourguignon, who approved of the protest and followed it on Skype. ?I hope that this action will help the Italian government reconsider CAM's situation,? she wrote?in The Guardian. ?Without funds, CAM will be closed and its collection will effectively cease to exist.?

Bourguignon?s piece was followed by many others, as meticulously recorded on CAM?s Facebook page.

Some contended?that the protest is only the provocative performance of an attention-seeking artist ? Manfredi is himself a painter, sculptor, and photographer?? and that because CAM is not technically a public museum, the government doesn't have to support it (although most private museums also receive some funding from the Ministry of Culture).?

But there is no doubt that Italy?s culture sector has been hit hard by cuts because of the economic crisis.?The Italian daily Republica reported?that between 2010 and 2011 the Ministry of Culture?s funding saw a 14.5 percent decrease, dropping from 1.7 million ($2.2 million) to 1.5 million euros.

Despite its world-class cultural wealth, Italy invests in the culture sector less than other countries. According to a government report, in 2010 the Ministry of Culture received only 0.21 percent of the country?s budget (compared, for instance, to 1 percent in France). It?s no surprise then that several prestigious institutions are going through a rough time.?

MAXXI, Rome?s contemporary museum, which opened only two years ago, has predicted losses of 11 million euros for 2012 through 2014. Naples?s and Parlermo?s contemporary art museums are also in deep financial trouble.

In the meantime, some organizations representing workers in the culture sector are protesting against low wages and the lack of adequate benefits. In a letter recently published in Corriere della Sera, they stressed the importance of what they do, which they say goes well beyond the workplace. ?We produce intangible but necessary goods on a daily basis: intelligence, relations, social welfare,? they wrote.

Investing in culture is also the recipe called for by renowned writer Dacia Maraini, who in a recent trip to the United States was surprised by the interest Americans still have in Italian culture and history. ?Shouldn?t we focus obstinately on what we can do best instead of competing with China in producing cheap jeans?? Maraini recently wrote in Corriere della Sera.

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Tuesday, May 8, 2012

Miranda Lambert Makes Up with Ashton Kutcher


Miranda Lambert didn't exactly love Ashton Kutcher's get-up at this year's Academy of Country Music Awards.

Was Ashton Kutcher making fun of country or is it just me? Watching it back now and I'm kinda wondering? the beloved country star asked about Kutcher presenting an award at the event, while donning a giant cowboy hat and belt buckle.

But whatever tension may have existed between the stars is now gone, as Lambert Tweeted the following photo of herself and the Two and a Half Men star at a pre-Kentucky Derby charity event Saturday night:

Miranda Lambert and Ashton Kutcher

"Here it is y'all. He is sweet and lives country music! For real!" Miranda wrote along with the image.

It's nice to see this pair getting along. As for Lambert and Chris Brown? We probably shouldn't hold our breath for a similar type of detente.

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Want To Know What Apple Will Do Next In Mobile Commerce? Check Out The Pirq It?s Giving To Employees

Pirq screenshotAs device makers like RIM, Samsung and Nokia incorporate NFC technology into their mobile devices, Apple has been radio silent on what its plans will be in mobile commerce and payments. But a deal that is getting announced today could be a clue to one area where Apple might see a big opportunity. Apple has signed on with Pirq, a startup from Seattle, to offer food and drink daily deals to its employees in the Bay Area, with the service working by way of an iPhone app, location-based technology, and a Microsoft Tag code to redeem the discounts. A source tells TechCrunch that this is the first part of a potential "four phase" implementation that could see Apple offering a deals service out to all iPhone users.

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Arnold Schwarzenegger vs. the Wingnuts (Little green footballs)

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